Acetic Acid Glacial ACS Grade

Product Overview

Acetic Acid Glacial, ACS Grade, is a colorless, highly volatile liquid with a pungent vinegar-like odor, primarily composed of acetic acid (CH₃COOH) at a concentration of 99.7% (typical). This reagent meets ACS and USP-NF monographs for analytical and synthetic applications, providing strong acidity and reliable solvent properties suitable for high-purity laboratory and manufacturing environments. The material is supplied with a rigorous COA profile, including assay results by titration against standardized NaOH, low water content, and trace metal specifications designed to support precise analytical workflows and reproducible results in HPLC, spectroscopy, and chemical synthesis.

The product is intended for use in analytical laboratories and industrial settings where strict quality control, traceability, and compliance with industry standards are required. Key attributes such as low impurities (iron, chloride, sulfate, arsenic, and heavy metals within specified limits), and a narrow boiling range (118–120°C) enable accurate baseline stability in chromatographic and spectroscopic methods. Proper storage in compatible containers and adherence to handling guidelines helps preserve purity, minimize moisture uptake, and maintain consistent performance across batches.

Key Properties

• Property Name: Appearance – Colorless liquid
• Chemical Formula: CH₃COOH
• Molecular Weight: 60.05 g/mol
• Boiling Point: 118–120°C
• Specific Gravity: 1.0495 (at 20°C)
• Residue After Ignition: ≤ 0.001% (typical 0.0005%)
• Water Content: ≤ 0.3% (typical 0.1%)
• Iron (Fe): ≤ 0.2 ppm (typical 0.05 ppm)
• Chloride (Cl⁻): ≤ 0.5 ppm (typical 0.2 ppm)
• Sulfate (SO₄²⁻): ≤ 0.5 ppm (typical 0.2 ppm)
• Heavy Metals (as Pb): ≤ 0.5 ppm (typical 0.1 ppm)
• Arsenic (As): ≤ 0.01 ppm (typical 0.005 ppm)
• Residue After Ignition (with notes): ≤ 0.001% (typical 0.0005%; ACS grade alignment)
• Phosphate (PO4³⁻): ≤ 0.5 ppm (typical 0.2 ppm)
• Nitrite (NO₂⁻): ≤ 0.2 ppm (typical 0.05 ppm)

Common Applications

• Application Category: HPLC Mobile Phase – Used as a mobile phase component in reversed-phase chromatography to achieve separation of organic compounds with reliable pH control and low UV cutoff implications.
• Application Category: Spectroscopy Solvent – Serves as a baseline solvent in UV-Vis spectroscopy due to low UV cutoff and high purity, enabling accurate spectral measurements.
• Application Category: pH Adjuster – Employed in industrial and laboratory processes to adjust and stabilize acidic conditions for reactions and sample preparation.
• Application Category: Chemical Synthesis Reagent – Acts as a key reagent in pharmaceutical and fine chemical synthesis, supporting esterification, deprotection, and acylation steps.
• Application Category: Food Industry – Used as a preservative and acidity regulator in certain food processing workflows, leveraging its antimicrobial properties and regulatory acceptance.

Safety Precautions

Handle only in a well-ventilated area or fume hood. Store in cool, dry conditions away from direct sunlight in materials compatible with acetic acid (HDPE or glass). Transfer and use with appropriate PPE, including chemical-resistant gloves and splash protection, to prevent skin and eye exposure. Maintain containers closed when not in use and follow proper compatibility guidelines to avoid unexpected reactions with oxidizers or bases.

For spillages or accidental exposure, evacuate the area if needed and follow standard emergency procedures. In case of skin or eye contact, rinse immediately with abundant water for several minutes and seek medical attention if irritation persists. Inhalation requires moving to fresh air and monitoring for signs of respiratory irritation. In case of ingestion, do not induce vomiting; rinse mouth and seek medical guidance promptly. Refer to the SDS for detailed emergency response steps and first-aid measures.

Benefits

✔ High Purity ACS Grade – Meets ACS/USP-NF monographs with precise assay, low water, and controlled impurity profile for analytical reliability.
✔ Analytical Consistency – Narrow boiling range, stable refractive index, and low impurity levels support reproducible chromatographic and spectroscopic results.