30% Propylene Glycol USP Grade

Product Overview

30% Propylene Glycol USP Grade is a clear, colorless liquid comprising propylene glycol and water in a defined 30% solution. It is produced to USP-grade specifications, ensuring a high level of chemical purity suitable for pharmaceutical, cosmetic, and analytical applications. The product exhibits a low toxicity profile and excellent solvent properties, making it a versatile humectant and solvent across multiple industries. Its composition is tightly controlled to minimize impurities, supporting consistent formulation behavior and reliable performance in sensitive processes such as HPLC mobile phases, pharmaceutical vehicle applications, and antifreeze formulations. Typical assay accuracy is achieved through standardized titration methods, with a typical assay around 30 wt% and a narrow color specification, supporting traceability to USP-NF monographs. The product is designed for storage under controlled conditions to preserve quality and reduce microbial growth, ensuring consistent batch-to-batch performance. This USP-grade propylene glycol solution also aligns with industry standards to support quality control and regulatory compliance in regulated environments.

Its utility spans analytical chemistry, food, automotive, and cosmetic sectors, where precise solvent behavior, low volatility, and favorable compatibility with water enable robust formulation design. The 30% solution provides a balance of solvency and miscibility, enabling controlled solvation and moisture retention in various matrices. The product’s defined properties support predictable processing conditions, helping laboratories and manufacturers maintain reproducible results in method development, formulation iteration, and quality assurance testing.

Key Properties

• Appearance: Clear, colorless liquid
• Chemical Formula: C₃H₈O₂
• Molecular Weight: 76.09 g/mol
• Boiling Point: 188.2°C
• Specific Gravity (20°C): 1.03–1.034 (typical 1.032)
• Specific Gravity (25°C): 1.027–1.033 (typical 1.030)
• Water Content (Karl Fischer): ≤ 0.2% (typical 0.1%)
• Residue on Ignition: ≤ 0.01% (typical 0.005%)
• Chloride (Cl): ≤ 25 ppm (typical 10 ppm)
• Nitrate (NO₃⁻): ≤ 5 ppm (typical 2 ppm)
• Arsenic (As): ≤ 0.1 ppm (typical 0.02 ppm)
• Heavy Metals (as Pb): ≤ 0.5 ppm (typical 0.1 ppm)
• Iron (Fe): ≤ 0.2 ppm (typical 0.05 ppm)

Common Applications

• HPLC Mobile Phase: Industry-standard component in reversed-phase chromatography for separating organic compounds with controlled solvent strength and compatibility with detection methods.
• Humectant in Food Products: Moisture retention agent that helps maintain texture and shelf life in formulated foods while meeting regulatory purity standards.
• Solvent in Pharmaceutical Formulations: Vehicle for active pharmaceutical ingredients, aiding solubility and stability in various dosage forms.
• Antifreeze Component: Used in automotive coolants for its favorable freezing and boiling point characteristics, contributing to system protection in low-temperature environments.
• Cosmetic Ingredient: Moisturizing vehicle in skin care and personal care products, providing viscosity control and favorable miscibility with water and other solvents.

Safety Precautions

Handle and store the product in a cool, dry place away from direct sunlight. Use materials compatible with propylene glycol, such as HDPE or glass, and ensure adequate ventilation to minimize inhalation exposure. Personal protective equipment, including gloves and goggles, should be worn during handling and transfer to prevent skin and eye contact. Follow standard operating procedures and confirm compatibility with downstream equipment to avoid unintended reactions or contamination.

For exposure management, maintain good housekeeping to minimize aerosol or vapor formation. In case of spills, evacuate the area if necessary and dispose of waste in accordance with local, state, and federal regulations. The product complies with USP-NF monographs; however, always consult the SDS for detailed hazard statements, first aid measures, and emergency procedures applicable to your specific use case and local regulatory requirements.

Benefits

✔ USP-Grade purity – Meets USP-NF monograph requirements, ensuring high-quality solvent performance and regulatory compatibility.

✔ Low toxicity profile – Suitable for pharmaceutical, cosmetic, and food-related applications when used within approved concentrations.