Methyl n-Propyl Ketone (MPK) ACS

Product Overview

Methyl n-Propyl Ketone (MPK) ACS is a colorless, flammable liquid with a characteristic ketone odor that underscores its role as a high-purity solvent in demanding industrial processes. As an ACS-grade 2-pentanone, MPK offers reliable solvency with a moderate evaporation rate, enabling precise formulation control in analytical and coating applications. The product is manufactured to meet stringent purity specifications and supported by GC-FID assay data to ensure a typical assay of 99.8% with a range of 99–100.5% for batches, aligning with ACS and USP-NF monograph expectations for reagents used in analytical and manufacturing environments. The material is stable under recommended handling and storage conditions, and it adheres to relevant safety and quality standards to support reproducible results in laboratory and production settings.

MPK is widely utilized as a solvent in analytical chemistry, coatings, and pharmaceutical extraction processes due to its compatibility with a broad range of polar and nonpolar solutes. Its physicochemical properties— including a boiling range of 102–104°C, a low water content, and a controlled acidity—enable consistent performance in HPLC mobile phases, coating formulations, and organic syntheses. With established storage, handling, and QC practices, MPK ACS provides dependable solvent performance while maintaining compliance with industry standards and safety requirements.

Key Properties

• Property Name: MPK (Methyl n-Propyl Ketone) – ACS Grade
• Chemical Formula: C₅H₁₀O
• Molecular Weight: 86.13 g/mol
• Boiling Point: 102–104°C
• Specific Gravity (20°C): 0.805 (typical)
• Density (25°C): 0.805 g/mL
• Vapor Pressure (20°C): 30 mmHg
• Viscosity (25°C): 0.45 cP
• Refractive Index (20°C): 1.392
• Water Content: 0.02% typical, up to 0.05% max
• pH/Acidity (Meq/g): ≤0.0003 meq/g max, typical 0.0001
• Assay (GC-FID): 99.0–100.5% (typical 99.8%)
• Color (APHA/Hazen): Max 5 (typical 2)

Common Applications

• HPLC Mobile Phase: Commonly used as a mobile phase component in reversed-phase high-performance liquid chromatography for separating organic compounds, providing compatible solvent strength and peak shape.
• Solvent for Coatings: Utilized as a solvent in the formulation of paints, coatings, and adhesives due to its effective solvency and evaporation profile.
• Extraction Solvent (Pharmaceutical): Employed in the extraction of active pharmaceutical ingredients from natural sources with favorable selectivity and carry-through properties.
• Intermediate in Organic Synthesis: Serves as an essential building block in the synthesis of diverse organic compounds, enabling downstream transformations.
• Cleaning Agent (Industrial): Used to remove grease and oils from machinery and equipment, offering effective sanitization with manageable residue characteristics.

Safety Precautions

Handle MPK ACS in a well-ventilated area using appropriate PPE, including chemical-resistant gloves, goggles or face shield, and a lab coat. Store in a cool, dry, well-ventilated area away from heat sources, directly oxidizing agents, and acids, using HDPE or glass containers to minimize container interactions. Maintain separation from ignition sources and ensure proper grounding during transfer to reduce vapor hazards. Follow storage temperature and humidity guidelines and minimize moisture ingress to preserve solvent performance.

Additional safety considerations include adherence to regulatory labeling and SDS guidance: MPK is classified as Flammable Liquid (H225), Eye Irritant (H319), and may cause drowsiness or dizziness (H336). In case of exposure, eyewash or emergency showers should be readily accessible; inhalation requires moving to fresh air and seeking medical attention if symptoms persist. Ingestion and skin contact procedures involve rinsing with water and seeking medical advice for irritation or adverse reactions. Transport follows UN 1230, Methyl n-Propyl Ketone, Class 3, Packing Group II, under appropriate carrier regulations.

Benefits

✔ High Purity ACS Grade – Meets ACS and USP-NF monograph expectations, with tight GC-FID assay control and low impurity levels for analytical and formulation reliability.
✔ Reliable Solvent Performance – Consistent solvency, moderate evaporation rate, and compatible with water, ethanol, and ether systems to support multi-step processes.
✔ Quality and Traceability – Thorough QC data (water, color, iron, heavy metals, acidity) and clear certificate of analysis enable traceable batch-to-batch performance.
✔ Safety and Regulatory Alignment – Comes with SDS compliance and standardized handling and safety recommendations suitable for industrial and laboratory environments.