Isopropyl Acetate 99.98%

Product Overview

Isopropyl Acetate 99.98% is a colorless, highly flammable liquid characterized by a fruity, sweet odor. Formed by the esterification of isopropanol and acetic acid, this reagent delivers excellent solvency and fast evaporation, making it a versatile solvent for analytical and industrial formulations. The product is supplied to ACS Reagent Grade standards with stringent impurity controls, including trace aldehydes, sulfates, chlorides, and heavy metals, ensuring high purity and consistent performance in precision applications. Typical assay ranges are 99.5–100.5 wt% (GC with calibrated internal standard), with a typical value near 99.9 wt%, supporting reliable solvent behavior in chromatography, coatings, and extraction processes.

Its low acidity, controlled water content, and low residue after ignition contribute to stable baseline performance in HPLC methods and gradient systems, while the refractive index at 20°C and specific gravity near 0.872 g/mL provide fast QC checks during manufacturing. The product is suitable for use in inert atmospheres to minimize moisture uptake, and is packaged in materials compatible with isopropyl acetate, such as HDPE or glass, to preserve purity during storage and handling.

Key Properties

• Property Name: Isopropyl Acetate (IUPAC: Propan-2-yl acetate)
• Chemical Formula: C₅H₁₀O₂
• Molecular Weight: 102.13 g/mol
• Boiling Point: 88-90°C
• Specific Gravity (25°C): 0.872 g/mL (0.868–0.878 range)
• Specific Gravity (20°C): 0.872 g/mL (0.867–0.878 range)
• Residue After Ignition: ≤0.01% (typical 0.005%)
• Chloride (Cl): ≤2 ppm (typical 0.5 ppm)
• Nitrate (NO₃⁻): ≤2 ppm (typical 0.5 ppm)
• Ammonium (NH₄⁺): ≤1 ppm (typical 0.2 ppm)
• Sulfate (SO₄²⁻): ≤2 ppm (typical 0.5 ppm)
• Arsenic (As): ≤0.01 ppm (typical 0.003 ppm)
• Heavy Metals (as Pb): ≤0.05 ppm (typical 0.01 ppm)
• Iron (Fe): ≤0.2 ppm (typical 0.05 ppm)
• Copper (Cu): ≤0.2 ppm (typical 0.05 ppm)
• Manganese (Mn): ≤0.2 ppm (typical 0.05 ppm)
• Nickel (Ni): ≤0.1 ppm (typical 0.02 ppm)
• Lead (Pb): ≤0.05 ppm (typical 0.01 ppm)
• Zinc (Zn): ≤0.5 ppm (typical 0.1 ppm)
• Aluminum (Al): ≤0.2 ppm (typical 0.05 ppm)
• Chromium (Cr): ≤0.1 ppm (typical 0.02 ppm)
• Cobalt (Co): ≤0.05 ppm (typical 0.01 ppm)
• Calcium (Ca): ≤20 ppm (typical 5 ppm)
• Sodium (Na): ≤5 ppm (typical 2 ppm)
• Potassium (K): ≤5 ppm (typical 2 ppm)
• Water (H₂O): ≤0.2% (typical 0.05%)
• Acidity (meq/g): ≤0.001 (typical 0.0005)
• Aldehydes: ≤10 ppm (typical 2 ppm)
• Vapor Pressure (20°C): 30 mmHg
• Viscosity (20°C): 0.4–0.45 cP (typical 0.45 cP)
• Refractive Index (20°C): 1.375
• Partition Coefficient (logP): 1.9
• Decomposition Temperature: Not expected under normal handling (typical 180°C in instrumentation studies)
• Assay (GC): 99.5–100.5 wt% (typical 99.9 wt%)
• Appearance: Colorless liquid
• Odor: Fruity, sweet odor
• CAS: 108-21-4
• Vapor Density (Air = 1): ~2.0
• Solubility: Soluble in organic solvents; slightly soluble in water

Common Applications

• HPLC Mobile Phase: Commonly used as a mobile phase component in reversed-phase high-performance liquid chromatography for separating organic compounds.
• Solvent for Coatings: Utilized as a solvent in paints, coatings, and adhesives due to its effective solvency and evaporation rate.
• Extraction Medium: Used in liquid-liquid extraction processes for isolating pharmaceutical intermediates.
• Cleaning Agent: Serves as a cleaning agent for removing residues and contaminants from various surfaces.
• Flavoring Agent: Employed as a flavoring agent in food products due to its fruity aroma.

Safety Precautions

Handling and storage should be conducted in a well-ventilated area away from heat, sparks, and open flames. Keep containers tightly closed when not in use, and store in compatible materials such as HDPE or glass. Use appropriate PPE including chemical-resistant gloves, goggles, and splash protection. Maintain inert atmosphere where applicable to minimize moisture uptake and ensure consistent quality. Follow ignition control practices and ensure proper grounding of containers during transfers to prevent static discharge. Adhere to regulatory storage guidelines and local fire codes; keep away from oxidizers and incompatible substances.

Additional safety considerations follow SDS guidance: Isopropyl Acetate is a highly flammable liquid and vapor (H225) and may cause serious eye irritation (H319) and drowsiness or dizziness (H336). In case of exposure, eyes should be rinsed cautiously with water for several minutes; skin contact requires thorough washing with soap and water; inhalation warrants fresh air and medical evaluation if symptoms persist; ingestion should not induce vomiting and medical guidance sought if unwell. Transported under UN 1230, Isopropanol, Class 3, Packing Group II.

Benefits

✔ High Purity ACS Grade – Meets ACS Reagent Grade specifications with tight control of trace metals and aldehydes for reliable analytical performance.
✔ Excellent Solvency and Evaporation – Rapid drying solvent suitable for coatings, adhesives, and analytical workflows, reducing process times and solvent residuals.