Isopropyl Acetate 99.98% ACS Grade

Product Overview

Isopropyl Acetate 99.98% ACS Grade is a highly pure, colorless liquid solvent with a characteristic fruity odor, designed for demanding analytical and industrial applications. Its ester of isopropanol and acetic acid provides excellent solvency for a wide range of organic compounds while maintaining relatively low toxicity when handled under standard laboratory conditions. The material is supplied with ACS Reagent Grade compliance, meeting or exceeding the requirements of Reagent Chemicals, 11th Edition, and USP-NF Monograph standards, ensuring consistent batch-to-batch performance for precision applications such as HPLC mobile phases, coating formulations, and pharmaceutical extraction processes. The compound’s volatility, low residue after evaporation, and favorable refractive index support reliable quantitative analyses and reproducible coating formulations in regulated environments.

The product is manufactured and tested to stringent specifications, including GC-FID assay accuracy (99–100% with typical 99.8%), APHA color ≤5 (typical 3), and a narrow impurity profile for key ions and metals. The low acidity (≤0.0003 meq/g) and minimal water content (≤0.05% w/w) help minimize baseline drift in gradient HPLC and reduce potential hydrolytic effects in solvent blends. Its compatibility with HDPE or glass containers, combined with proper storage, maintains solvent integrity over a typical shelf life of 24 months when stored under recommended conditions.

Key Properties

• Appearance: Colorless liquid
• Odor: Fruity odor
• Chemical Formula: C₅H₁₀O₂
• Molecular Weight: 102.13 g/mol
• CAS: 108-21-4
• Boiling Point (range): 88-90°C
• Freezing Point: -50°C
• Specific Gravity (20°C): 0.875 (range 0.872–0.878)
• Density (25°C): 0.873 g/mL
• Vapor Pressure (20°C): 30 mmHg
• Viscosity (20–25°C): 0.95 cP
• Refractive Index (20°C): 1.375
• Partition Coefficient (logP): 1.18
• Residue After Ignition: ≤0.01% (typical 0.005%)
• Water Content: ≤0.05% (typical 0.02%)
• Chloride (Cl): ≤20 ppm (typical 5 ppm)
• Nitrate/Nitrite (NO₃⁻): ≤20 ppm (typical 5 ppm)
• Ammonium (NH₄⁺): ≤2 ppm (typical 1 ppm)
• Heavy Metals (as Pb): ≤0.5 ppm (typical 0.2 ppm)
• Arsenic (As): ≤0.5 ppm (typical 0.2 ppm)
• Lead (Pb): ≤0.2 ppm (typical 0.05 ppm)
• Chromium (Cr): ≤0.2 ppm (typical 0.05 ppm)
• Iron (Fe): ≤0.5 ppm (typical 0.1 ppm)
• Acidity (meq/g): ≤0.0003 (typical 0.0001)
• Aluminum (Al): ≤0.5 ppm (typical 0.1 ppm)
• Sulfate (SO₄²⁻): ≤50 ppm (typical 20 ppm)
• Sodium (Na): ≤5 ppm (typical 2 ppm)

Common Applications

• Application Category: HPLC Mobile Phase – Used as a component in reversed-phase mobile phases to improve separation of organic compounds with favorable volatility and low UV absorbance impact in detector windows.
• Application Category: Solvent for Coatings – Provides excellent solvency for paints, coatings, and adhesives, enabling uniform film formation and controlled evaporation rates.
• Application Category: Extraction Solvent – Employed in extraction processes to isolate active pharmaceutical ingredients, offering high solubility for organics and manageable residual profiles.
• Application Category: Cleaning Agent – Effective for residue and contaminant removal on surfaces and equipment in manufacturing environments, with rapid evaporation minimizing downtime.
• Application Category: Flavoring Agent – Contributes fruity aroma in food-grade flavor formulations (subject to regulatory compliance for specific products).

Safety Precautions

Handling and storage should be performed in a well-ventilated area away from heat sources. Store in cool, dry conditions in containers of HDPE or glass, and keep away from direct sunlight and incompatible materials such as strong oxidizers and concentrated acids. Use appropriate PPE, including chemical-resistant gloves, eye protection, and lab coat or coveralls to minimize skin and eye exposure. Ensure proper grounding and bonding when transferring liquids to prevent static discharge, given the material’s flammable nature.

Additional safety considerations include monitoring for vapor exposure in accordance with local regulations, maintaining suitable fire suppression measures (Class 3 flammable liquid), and following emergency procedures in the event of spills or accidental releases. The product is flammable and can cause serious eye irritation and central nervous system effects; avoid inhalation and contact with skin or eyes. Follow established exposure limits and consult the SDS for detailed first-aid, spill response, and incident reporting guidance.

Benefits

✔ High Purity ACS Grade – Consistent composition and low impurity profile suitable for sensitive analytical methods and high-performance separations.
✔ Excellent Solvency – Broad compatibility with organic matrices and coatings, enabling robust formulation performance.
✔ Low Acidity – Minimizes baseline drift in gradient HPLC and reduces hydrolysis risk in solvent blends.
✔ Controlled Volatility – Supports rapid yet predictable evaporation for efficient processing and drying.
✔ Regulatory Compliance – Meets ACS Reagent Grade and USP-NF standards, with trace metal control suitable for pharmaceutical and analytical environments.