Cyclohexanone ACS Grade

Product Overview

Cyclohexanone ACS Grade (2-Cyclohexanone; Cyclohexanone 99%) is a colorless, flammable liquid (C6H10O) with a distinctive detergent-like odor. It serves as a high-purity solvent and a versatile intermediate in the production of nylon and various chemical derivatives, offering excellent solvency for a wide range of organic compounds. The ACS-grade specification ensures adherence to stringent impurity limits, enabling reliable performance in sensitive analytical and manufacturing processes. Typical purity is 99.5% with a titration-based assay (NaOH) confirming assay in the range of 99–100%. The product is supplied with detailed analytical data to support quality control in pharmaceutical, coating, and polymer applications.

Its favorable physical properties, including a low boiling range (155–157°C), moderate vapor pressure at 20°C, and good miscibility with water, ethanol, and ether, make Cyclohexanone ACS Grade suitable for use in HPLC mobile phases, surface coatings, and as an intermediate in synthetic pathways. When used as a solvent, it provides consistent solvency for a broad spectrum of organics, while maintaining process integrity through low acidity and tightly controlled impurity levels. This product is manufactured to meet ACS Reagent Grade and USP-NF Monograph standards, reflecting rigorous quality and traceability for industrial and laboratory environments.

Key Properties

• Appearance: Colorless liquid
• Chemical Formula: C₆H₁₀O
• Molecular Weight: 98.15 g/mol
• Boiling Point: 155–157°C
• Freezing Point: −31°C
• Specific Gravity (20°C): 0.947 (typical; 0.942–0.952)
• Density (25°C): 0.948 g/mL
• Vapor Pressure (20°C): 4.4 mmHg
• Viscosity (25°C): 0.89 cP
• Refractive Index (20°C): 1.428
• Assay (wt.%): 99.5% typical (min 99, max 100); test method: Titration with standardized NaOH
• Residue on Evaporation (wt.%): 0.003% typical; max 0.01% (gravimetric)
• Acidity (meq/g): 0.00015 typical; max 0.0003; test method: Titration with standardized base
• Aldehydes (ppm): 2 typical; max 10; test method: GC
• Chloride (ppm): 1 typical; max 2; test method: IC
• Nitrate/Nitrite (ppm NO3-): 0.3 typical; max 1; test method: IC
• Ammonium (ppm): 0.2 typical; max 0.5; test method: IC
• Sulfate (ppm): 0.7 typical; max 2; test method: IC
• Phosphate (ppm): 0.1 typical; max 0.5; test method: IC
• Arsenic (ppm as As): 0.02 typical; max 0.1; test method: ICP-MS
• Heavy Metals (as Pb, ppm): 0.1 typical; max 0.5; test method: ICP-MS
• Iron (ppm): 0.05 typical; max 0.2; test method: ICP-OES
• Chromium (ppm): 0.1 typical; max 0.5; test method: ICP-OES
• Other Metals (ppm): Cu, Mn, Ni, Co, Zn, Al, Sn not exceeding typical values shown; test methods: ICP-OES
• Chlorine, Fluoride, and Halide-Related Impurities: N/A to pure cyclohexanone; test methods IC/GC as applicable
• Appearing Odor: Sweet, pungent odor
• Assay Method Reference: Titration with standardized NaOH

Common Applications

• Application Category: HPLC Mobile Phase – Used as a solvent component in reversed-phase HPLC for separating organic compounds with reliable baseline stability and low UV absorbance interference.
• Solvent for Coatings – Employed in paints, coatings, and adhesives for its broad solvency and controlled evaporation characteristics, aiding film formation and curing profiles.
• Intermediate in Synthesis – Serves as a key precursor in nylon production and other polymerization pathways, contributing to process efficiency and product quality.
• Extraction Solvent – Applied in the extraction of active pharmaceutical ingredients from plant matrices, offering selective solubility and compatibility with downstream purification steps.
• Cleaning Agent – Used in research laboratories for glassware and equipment cleaning due to its solvency and compatibility with various detergents and residues.

Safety Precautions

Handling Cyclohexanone ACS Grade requires strict adherence to recommended PPE, including chemical-resistant gloves, splash goggles or face shield, and appropriate lab coat or ASTM-rated apparel. Store in a cool, well-ventilated area away from heat sources in HDPE or glass containers, and keep away from oxidizers and strong acids. Use in a properly ventilated fume hood to minimize inhalation exposure; ensure containment to prevent vapor accumulation and potential ignition sources due to its flammable nature. Follow storage guidelines to avoid moisture uptake and hydrolytic impacts on purity, and ensure containers are sealed when not in use.

First safety paragraph: The SDS indicates Cyclohexanone is a highly flammable liquid and vapor (Flam. Liq. 2) with potential acute toxicity and eye irritation. Handle with appropriate fire protection measures (flash point 11°C); use explosion-proof equipment in facilities where solvent vapors may accumulate. Maintain adequate ventilation and grounding to prevent static discharge. Personal protective equipment should include chemical-resistant gloves, safety goggles, and a respirator if exposure is anticipated to exceed occupational exposure limits.

Benefits

✔ High Purity and Compliance – Meets ACS Reagent Grade and USP-NF Monograph standards with tight impurity control for reliable analytical and manufacturing performance.
✔ Excellent Solvent Properties – Broad solvency for organic compounds with stable chromatographic behavior and minimal acid contaminants that could affect sensitive analyses.
✔ Analytical Confidence – Comprehensive impurity profile (low aldehydes, metals, and halides) supports trace level requirements in pharmaceutical and specialty chemical applications.
✔ Quality and Traceability – Comprehensive test data (assay, residue, acidity, and major element content) support QA/QC programs and regulatory compliance.